TAKE THE NINLARO^® (IXAZOMIB) COMBINATION WHEREVER YOU GO

What is the NINLARO treatment combination* dosing schedule?

The all-oral NINLARO treatment combination gives you some time back as well as for your loved ones and care partners. With no travel to the clinic required for dosing of the all-oral NINLARO treatment combination*, NINLARO is taken just once a week for 3 weeks each month—at home, on the go, or wherever life takes you. NINLARO is taken along with 2 other oral medications, REVLIMID^® (lenalidomide) and dexamethasone, as part of a three-pill combination, in 4-week cycles.

*NINLARO + lenalidomide + dexamethasone.

The NINLARO treatment combination for a 28-day cycle

The NINLARO® (ixazomib) treatment combination 28-day dosing schedule.

How should I take NINLARO?

Staying on top of your dosing schedule is key. The information in this section is based on how NINLARO was approved by the FDA. Please make sure to take the NINLARO treatment combination as prescribed by your healthcare provider.

NINLARO is different than other proteasome inhibitors because it is the first and only proteasome inhibitor that you can take on-the-go in capsule form. NINLARO is taken orally, so you don’t need to travel to a clinic or worry about scheduling extra appointments for injections or infusions. You still need to have your regular visits with your doctor.

NINLARO comes in a package that is different from other packaging you may have opened in the past. Get helpful step-by-step instructions for opening your NINLARO package.

Take each dose of NINLARO at about the same time of day each week.

Take each dose of NINLARO at least 1 hour before or at least 2 hours after food.

Swallow NINLARO capsules whole with water. Do not crush, chew, or open the capsule.

Do not take NINLARO at the same time as dexamethasone.

Take NINLARO exactly as your healthcare provider tells you to take it.

Your healthcare provider will do blood tests during treatment with NINLARO to check for side effects.

What if I miss a dose?

If you miss a dose of NINLARO, you can take the missed dose as long as the next scheduled one is more than 3 days away. NINLARO is absorbed into your body very quickly.

If you vomit after taking a dose of NINLARO, do not repeat the dose. Instead, take your next dose of NINLARO on the next scheduled day and time.

What are some tips for staying on treatment?

Partner with your care team

Even with the best intentions, it’s possible to miss doses of your treatment. You may be balancing dosing schedules, be concerned about side effects, or just forget because you’re human. Staying on therapy is about partnership. You and your healthcare team should work together to make decisions about your care. The goal is for you to have an understanding of, and control in, your treatment plan.

Make every dose everyone's responsibility

The good news is that your healthcare team, care partners, and loved ones can all help with adherence or taking all medications as prescribed by your healthcare provider. This way, the responsibility doesn't fall entirely on you. Talk with your care team about the importance of adherence and how you can work together to stay on treatment. When talking with your healthcare team specifically, consider the using the conversation starter to start thinking of questions to ask.

Ask questions

Make sure that you fully understand your treatment and clarify anything that's confusing. Ask for information about potential side effects of treatment. Always talk to your doctor, as there are changes that can be made to your dose if you experience certain side effects.

Remember to take your medication

Forgetting to take your medicine is a common reason for nonadherence. The important thing is that you are open with your care team and take steps to prevent it from happening.

How can I remember to take my medication?

Build a routine and take your medication during a certain activity (eg, brushing your teeth, getting ready for the day)

Keep track of doses you've taken by recording each one in a medication diary

Set alarms (eg, watches, smartphones, text/call reminders)

What are some important things to remember when taking NINLARO?

For your safety, NINLARO has been sealed in a protective slipcase. You and your care team should keep NINLARO in this package until it's time to take your medication
Avoid direct contact with the capsule contents
If you accidentally get powder from the NINLARO capsule on your skin, wash the area well with soap and water
If you accidentally get powder from the NINLARO capsule in your eyes, flush your eyes well with water
Store NINLARO capsules in the original packaging until just before each use
Store NINLARO at room temperature. Do not store above 30°C (86°F)
Do not freeze NINLARO
Keep NINLARO and all medicines out of the reach of children

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IMPORTANT SAFETY INFORMATION FOR NINLARO^® (ixazomib)

NINLARO may cause serious side effects, including:

Low platelet counts (thrombocytopenia) are common with NINLARO and can sometimes be serious. You may need platelet transfusions if your counts are too low. Tell your healthcare provider if you have any signs of low platelet counts, including bleeding and easy bruising.

Stomach and intestinal (gastrointestinal) problems. Diarrhea, constipation, nausea, and vomiting are common with NINLARO and can sometimes be severe. Call your healthcare provider if you get any of these symptoms and they do not go away during treatment with NINLARO. Your healthcare provider may prescribe medicine to help treat your symptoms.

Nerve problems are common with NINLARO and may also be severe. Tell your healthcare provider if you get any new or worsening symptoms including: tingling, numbness, pain, a burning feeling in your feet or hands, or weakness in your arms or legs.

Swelling is common with NINLARO and can sometimes be severe. Tell your healthcare provider if you develop swelling in your face, arms, hands, legs, ankles, or feet, or if you gain weight from swelling.

Skin reactions. Rashes are common with NINLARO. NINLARO can cause rashes and other skin reactions that can be serious and can lead to death. Tell your healthcare provider right away if you get a new or worsening rash, severe blistering or peeling of the skin, or mouth sores.

Thrombotic microangiopathy (TMA). This is a condition involving blood clots and injury to small blood vessels that may cause harm to your kidneys, brain, and other organs, and may lead to death. Get medical help right away if you get any of the following signs or symptoms during treatment with NINLARO: fever, bruising, nose bleeds, tiredness, or decreased urination.

Liver problems. Tell your healthcare provider if you get these signs of a liver problem: yellowing of your skin or the whites of your eyes; pain in your right upper stomach-area (abdomen).

Other common side effects of NINLARO include low white blood cell counts (neutropenia) and bronchitis.

Tell your healthcare provider if you get new or worsening signs or symptoms of the following during treatment with NINLARO:

skin rash and pain (shingles) due to reactivation of the chicken pox virus (herpes zoster)

blurred vision or other changes in your vision, dry eye, and pink eye (conjunctivitis)

These are not all the possible side effects of NINLARO. Talk to your healthcare provider for medical advice about side effects. You may report side effects to Takeda at 1-844-217-6468 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before taking NINLARO, tell your healthcare provider about all your medical conditions, including if you:

have liver problems.

have kidney problems or are on dialysis.

are pregnant or plan to become pregnant. NINLARO can harm your unborn baby.
Females who are able to become pregnant:

Avoid becoming pregnant during treatment with NINLARO.
Your healthcare provider will do a pregnancy test before you start treatment with NINLARO.
You should use effective non-hormonal birth control during treatment and for 90 days after your last dose of NINLARO. If using hormonal contraceptives (for example, birth control pills), you should also use an additional barrier method of contraception (for example, diaphragm or condom). Talk to your healthcare provider about birth control methods that may be right for you during this time.
Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with NINLARO.
Males with female partners who are able to become pregnant:
You should use effective birth control during treatment and for 90 days after your last dose of NINLARO.
Tell your healthcare provider right away if your partner becomes pregnant or thinks she may be pregnant while you are being treated with NINLARO.

are breastfeeding or plan to breastfeed. It is not known if NINLARO passes into breast milk, if it affects an infant who is breastfed, or breast milk production. Do not breastfeed during treatment with NINLARO and for 90 days after your last dose of NINLARO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Talk to your healthcare provider before starting any new medicines during treatment with NINLARO.

Taking too much NINLARO (overdose) can cause serious side effects, including death. If you take more NINLARO than instructed by your healthcare provider, call your healthcare provider right away or go to the nearest hospital emergency room right away. Take your medicine pack with you.

TAKE THE NINLARO^® (IXAZOMIB) COMBINATION WHEREVER YOU GO

What is the NINLARO treatment combination* dosing schedule?

The NINLARO treatment combination for a 28-day cycle

How should I take NINLARO?

What if I miss a dose?

What are some tips for staying on treatment?

How can I remember to take my medication?

What are some important things to remember when taking NINLARO?

Takeda Oncology
Here2Assist^® patient support

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IMPORTANT SAFETY INFORMATION, INDICATION, AND USAGE

NINLARO may cause serious side effects, including:

Before taking NINLARO, tell your healthcare provider about all your medical conditions, including if you:

What is NINLARO?

What is the NINLARO treatment combination* dosing schedule?

The NINLARO treatment combination for a 28-day cycle

How should I take NINLARO?

What if I miss a dose?

What are some tips for staying on treatment?

How can I remember to take my medication?

What are some important things to remember when taking NINLARO?

Takeda OncologyHere2Assist® patient support

Lab testtracker

IMPORTANT SAFETY INFORMATION, INDICATION, AND USAGE

Takeda Oncology
Here2Assist^® patient support

Lab test
tracker