IN THEIR WORDS:
REAL PATIENT
STORIES

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This video features a real patient sharing his experience living with multiple myeloma and being treated with NINLARO®. The information in this video is based on his experience at the time of recording. Given the nature of multiple myeloma, experiences may change over time. This is Joe’s experience while taking NINLARO, and yours may be different.

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JOE:  I've been married for 48 years. We normally are early risers, so we get up anywhere from 5:30 to 6:30 in the morning.

We like to exercise as a way to keep ourselves active and keep our bodies active, and I feel it's important with my multiple myeloma to make sure that I keep myself in shape and maintain a good health.

JOE:  My name is Joe, I'm 69 years old and I'm living with multiple myeloma.

Before I was diagnosed with multiple myeloma, I had really no serious illnesses or complaints or problems at all.

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JOE: That's when he told us that I had, sorry, multiple myeloma and that was a shock. He brought in the whole team. He explained everything. He told me that I had two lesions on each of my femurs with the 30% bone loss and that it was something that I needed to take a look at now, not something that I could wait a year on. He said he would suggest that I go ahead and got into the protocol for a stem cell transplant and we kind of left the office that day in shock.

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JOE:  It was after the 100-day mark of getting the post stem cell transplant analysis, that it was kind of another shock as they came up and said that the results indicated I did not go into remission. It was a partial response. The numbers were low but not into, not zero. But then around the four-month mark, the numbers started to go up.

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JOE:  My numbers steadily kept going up and we were talking with the care team about what's the next step  and what kind of treatments were out there. They talked about this drug NINLARO.

VO:  NINLARO is a prescription medicine used to treat multiple myeloma in combination with the medicines, REVLIMID (lenalidomide) and dexamethasone in people who have received at least one prior treatment for their multiple myeloma. NINLARO should not be used to treat the following people unless they're participants in a controlled clinical trial: people who are receiving maintenance treatment or people who have been newly diagnosed with multiple myeloma. It is not known if NINLARO is safe and effective in children.

VO: Please see Important Safety Information for NINLARO at the end of this video.

[No voiceover]

JOE:  I've been on NINLARO now five years. And I got to say I'm extremely happy with the results so far. In my experience taking NINLARO, the side effects have really been very minimal.

VO: The most common side effects of NINLARO include low platelet counts, low white blood cell counts, diarrhea, constipation, nerve problems, nausea, swelling, rash, vomiting, and bronchitis.

JOE:  I mean, to me it's just the freedom to be able to conduct your life more independently and on your own. To be able to say, "You know, if I want to go somewhere today, I can go there and I can take this oral pill with me if I hadn't taken it yet." Versus, "Oh, I need to plan around the fact that I've got to be at the hospital tomorrow to get an infusion."

JOE: It was like the best of both worlds.

NINLARO gave me the ability to say, "Hey, I can still work. I can still travel. I don't have to be home and in the hospital on these days of the week and then try to get out on the road on the rest of the week. I can take my treatment with me and be able to work and have more of a full life from that possibility." 

JOE: We have a bucket list for my wife and I. We're looking at going to different hockey games where the Pittsburgh Penguins play and seeing every stadium they play in. And at the same time mix that in with seeing the grandsons and watching them grow up and playing their sports and doing their things. So there’s some big plans we have.

JOE:  With taking an oral medication versus an infusion, the ability to have freedom to conduct my life and lifestyle in a more normal manner.

Life with multiple myeloma has taught me that you need to value your experience and your life as it is and concentrate on those things that are important to you and your family.

VO: What is NINLARO?

NINLARO is a prescription medicine used to treat multiple myeloma in combination with the medicines REVLIMID® (lenalidomide) and dexamethasone, in people who have received at least one prior treatment for their multiple myeloma.

NINLARO should not be used to treat the following people, unless they are participants in a controlled clinical trial:

• people who are receiving maintenance treatment, or
• people who have been newly diagnosed with multiple myeloma.

It is not known if NINLARO is safe and effective in children.

Important Safety Information for NINLARO® (ixazomib)

NINLARO may cause serious side effects, including:

• Low platelet counts (thrombocytopenia) are common with NINLARO and can sometimes be serious. You may need platelet transfusions if your counts are too low. Tell your healthcare provider if you have any signs of low platelet counts, including bleeding and easy bruising.
• Stomach and intestinal (gastrointestinal) problems. Diarrhea, constipation, nausea, and vomiting are common with NINLARO and can sometimes be severe. Call your healthcare provider if you get any of these symptoms and they do not go away during treatment with NINLARO. Your healthcare provider may prescribe medicine to help treat your symptoms.
• Nerve problems are common with NINLARO and may also be severe. Tell your healthcare provider if you get any new or worsening symptoms including: tingling, numbness, pain, a burning feeling in your feet or hands, or weakness in your arms or legs.
• Swelling is common with NINLARO and can sometimes be severe. Tell your healthcare provider if you develop swelling in your face, arms, hands, legs, ankles, or feet, or if you gain weight from swelling.
• Skin reactions. Rashes are common with NINLARO. NINLARO can cause rashes and other skin reactions that can be serious and can lead to death. Tell your healthcare provider right away if you get a new or worsening rash, severe blistering or peeling of the skin, or mouth sores.
• Thrombotic microangiopathy (TMA). This is a condition involving blood clots and injury to small blood vessels that may cause harm to your kidneys, brain, and other organs, and may lead to death. Get medical help right away if you get any of the following signs or symptoms during treatment with NINLARO: fever, bruising, nose bleeds, tiredness, or decreased urination.
• Liver problems. Tell your healthcare provider if you get these signs of a liver problem: yellowing of your skin or the whites of your eyes; pain in your right upper area (abdomen).

Other common side effects of NINLARO include low white blood cell counts and bronchitis (neutropenia).

Tell your healthcare provider if you get new or worsening signs or symptoms of the following during treatment with NINLARO:

• skin rash and pain (shingles) due to reactivation of the chicken pox virus (herpes zoster)
• blurred vision or other changes in your vision, dry eye, and pink eye (conjunctivitis)

These are not all the possible side effects of NINLARO. Talk to your healthcare provider for medical advice about side effects. You may report side effects to Takeda at 1-844-217-6468 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before taking NINLARO, tell your healthcare provider about all your medical conditions, including if you:

• have liver problems.
• have kidney problems or are on dialysis.
• are pregnant or plan to become pregnant. NINLARO can harm your unborn baby.

Females who are able to become pregnant:

• Avoid becoming pregnant during treatment with NINLARO.
• Your healthcare provider will do a pregnancy test before you start treatment with NINLARO.
• You should use effective non-hormonal birth control during treatment and for 90 days after your last dose of NINLARO. If using hormonal contraceptives (for example, birth control pills), you should also use an additional barrier method of contraception (for example, diaphragm or condom). Talk to your healthcare provider about birth control methods that may be right for you during this time.
• Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with NINLARO.

Males with female partners who are able to become pregnant:
 

• You should use effective birth control during treatment and for 90 days after your last dose of NINLARO.
• Tell your healthcare provider right away if your partner becomes pregnant or thinks she may be pregnant while you are being treated with NINLARO.
• are breastfeeding or plan to breastfeed. It is not known if NINLARO passes into breast milk, if it affects an infant who is breastfed, or breast milk production. Do not breastfeed during treatment with NINLARO and for 90 days after your last dose of NINLARO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Talk to your healthcare provider before starting any new medicines during treatment with NINLARO.

Taking too much NINLARO (overdose) can cause serious side effects, including death. If you take more NINLARO than instructed by your healthcare provider, call your healthcare provider right away or go to the nearest hospital emergency room right away. Take your medicine pack with you. 
 

Please visit NINLARO.com for full Prescribing Information including Patient Information.

VO: NINLARO is a prescription medicine used to treat multiple myeloma in combination with the medicines REVLIMID® (lenalidomide) and dexamethasone, in people who have received at least one prior treatment for their multiple myeloma.

NINLARO should not be used to treat the following people, unless they are participants in a controlled clinical trial:

• people who are receiving maintenance treatment, or
• people who have been newly diagnosed with multiple myeloma.

It is not known if NINLARO is safe and effective in children.
 

This video features a real patient sharing their experiences living with multiple myeloma and being treated with NINLARO, also called ixazomib. These experiences are based on the patient’s experiences at the time of recording. Given the nature of multiple myeloma, experiences may change over time. These are Scott’s and Amy’s experiences while taking NINLARO, and yours may be different.
 

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NINLARO VPOP Series: NINLARO Patient Ambassador Scott & Amy

SCOTT: I’m living with multiple myeloma, and I’ve undergone several different therapies.
When my doctor brought up NINLARO as an appropriate option for me, I wanted to learn more because it is an all-oral option that I could take at home.
 

SCOTT: It meant I wouldn’t have to go to the hospital once a week to get an infusion.
 

AMY: Multiple myeloma is a complicated disease, and, since I’m my own advocate, I try to learn as much as I can about it, and I’m always open to other treatment options.
 

AMY: I remember after completing my prior therapy, I told my doctor I didn’t want to schedule my life around clinic appointments. I was eager to try the NINLARO regimen because it meant I could take my medication at home.
 

SCOTT: My doctor went over all the possible side effects of the NINLARO regimen, and that was really important to me. He told me if the side effects became a problem, I should give him a call right away. He also explained to me that in order for the NINLARO regimen to have the best possible chance of doing its job, I would have to take it exactly as prescribed.
 

AMY: With the NINLARO regimen, you have to take NINLARO along with dexamethasone and REVLIMID on specific days, and it can be a lot to remember. From the beginning, I decided to mark my NINLARO regimen days on my calendar, and I also set alarms on my phone, and that’s what I do today. And, of course, I always keep my NINLARO in its original packaging, and I keep it with my other medications, so I always know where it is.
 

SCOTT: Everyone is different as far as how they take their medication. What helps me remember when to take my NINLARO is I associate it with a certain day of the week, and I do the same for the other medications in the combination. I’ve gotten into a rhythm with it, and I’m sticking to it.
 

AMY: My doctor reminded me that the NINLARO regimen is helping me manage this disease, and we have to do whatever we can to stay on track with the treatment. So, I make it a point to only take the NINLARO regimen according to my doctor’s instructions.
 

SCOTT: I believe you have to take ownership of this cancer and respect it because it’s a smart cancer. That’s why it’s important to work with your healthcare team and follow their guidance.
 

AMY: This is how I look at it: I’m going to do everything I can to work with my healthcare team because I want to keep doing the things that I love.
 

VO: Talk with your doctor to find out if NINLARO is a treatment option for you. Please stay tuned for the Important Safety Information for NINLARO.
 

VO: Important Safety Information for NINLARO 
 

NINLARO may cause serious side effects, including:
 

Low platelet counts (thrombocytopenia) are common with NINLARO and can sometimes be serious. You may need platelet transfusions if your counts are too low. Tell your healthcare provider if you have any signs of low platelet counts, including bleeding and easy bruising.
 

Stomach and intestinal (gastrointestinal) problems. Diarrhea, constipation, nausea, and vomiting are common with NINLARO and can sometimes be severe. Call your healthcare provider if you get any of these symptoms and they do not go away during treatment with NINLARO. Your healthcare provider may prescribe medicine to help treat your symptoms.
 

Nerve problems are common with NINLARO and may also be severe. Tell your healthcare provider if you get any new or worsening symptoms including: tingling, numbness, pain, a burning feeling in your feet or hands, or weakness in your arms or legs.
 

Swelling is common with NINLARO and can sometimes be severe. Tell your healthcare provider if you develop swelling in your face, arms, hands, legs, ankles, or feet, or if you gain weight from swelling.
 

Skin reactions. Rashes are common with NINLARO. NINLARO can cause rashes and other skin reactions that can be serious and can lead to death. Tell your healthcare provider right away if you get a new or worsening rash, severe blistering or peeling of the skin, or mouth sores.
 

Thrombotic microangiopathy (TMA). This is a condition involving blood clots and injury to small blood vessels that may cause harm to your kidneys, brain, and other organs, and may lead to death. Get medical help right away if you get any of the following signs or symptoms during treatment with NINLARO: fever, bruising, nose bleeds, tiredness, or decreased urination.
 

Liver problems. Tell your healthcare provider if you get these signs of a liver problem: yellowing of your skin or the whites of your eyes; pain in your right upper stomach-area (abdomen).
Other common side effects of NINLARO include low white blood cell counts and bronchitis (neutropenia).
 

Tell your healthcare provider if you get new or worsening signs or symptoms of the following during treatment with NINLARO:

• skin rash and pain (shingles) due to reactivation of the chicken pox virus (herpes zoster)
• blurred vision or other changes in your vision, dry eye, and pink eye (conjunctivitis)

These are not all the possible side effects of NINLARO. Talk to your healthcare provider for medical advice about side effects. You may report side effects to Takeda at 1-844- 217-6468 or FDA at 1-800-FDA-1088. Before taking NINLARO, tell your healthcare provider about all your medical conditions, including if you:

• have liver problems.
• have kidney problems or are on dialysis.
• are pregnant or plan to become pregnant.

NINLARO can harm your unborn baby. Females who are able to become pregnant:

• Avoid becoming pregnant during treatment with NINLARO.
• Your healthcare provider will do a pregnancy test before you start treatment with NINLARO.
• You should use effective non-hormonal birth control during treatment and for 90 days after your last dose of NINLARO. If using hormonal contraceptives (for example, birth control pills), you should also use an additional barrier method of contraception (for example, diaphragm or condom). Talk to your healthcare provider about birth control methods that may be right for you during this time.

Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with NINLARO. Males with female partners who are able to become pregnant:

• You should use effective birth control during treatment and for 90 days after your last dose of NINLARO.
• Tell your healthcare provider right away if your partner becomes pregnant or thinks she may be pregnant while you are being treated with NINLARO.
• are breastfeeding or plan to breastfeed. It is not known if NINLARO passes into breast milk, if it affects an infant who is breastfed, or breast milk production. Do not breastfeed during treatment with NINLARO and for 90 days after your last dose of NINLARO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Talk to your healthcare provider before starting any new medicines during treatment with NINLARO.

Taking too much NINLARO (overdose) can cause serious side effects, including death. If you take more NINLARO than instructed by your healthcare provider, call your healthcare provider right away or go to the nearest hospital emergency room right away. Take your medicine pack with you. 
Please see Patient Information in the NINLARO (ixazomib) full Prescribing Information in the prescribing information tab on www.ninlaro.com.

Music Fade Out – No voiceover

Play Video

VO: NINLARO is a prescription medicine used to treat multiple myeloma in combination with the medicines REVLIMID® (lenalidomide) and dexamethasone, in people who have received at least one prior treatment for their multiple myeloma.

NINLARO should not be used to treat the following people, unless they are participants in a controlled clinical trial:

• people who are receiving maintenance treatment, or
• people who have been newly diagnosed with multiple myeloma.

It is not known if NINLARO is safe and effective in children.
 

This video features a real patient sharing their experiences living with multiple myeloma and being treated with NINLARO, also called ixazomib. These experiences are based on the patient’s experiences at the time of recording. Given the nature of multiple myeloma, experiences may change over time.
 

This is Gail’s experience while taking NINLARO, and yours may be different.
 

[No voiceover]
 

VO: Today we have the pleasure of hearing from Gail and her sister Paulette, NINLARO Ambassadors who will be sharing their experiences with NINLARO and living with multiple myeloma.
 

VO: It is important to remember that everyone’s experience with multiple myeloma is unique and you should talk with your own doctor about your diagnosis and individual treatment plans.
 

VO: Now please welcome Gail & Paulette!
 

+++ 14:31:37 +++ Gail: Before my diagnosis, I worked fulltime, I taught and took exercise classes and I competed in fitness shows. I was pretty healthy, no complaints. And by taking care of myself, I thought // I was investing in a healthy future. I told myself that I was going to be one of those really active senior citizens.
 

+++ 15:32:55 +++ One March, I started to notice unusual pains and twinges in my back. Things were really busy and exciting at work, and truthfully, up until that point in my life, I was not one to make regular visits to the doctor. But by June, I could not stand up straight.
 

+++ 15:31:34 +++ Debilitating back pain finally took me to my primary care doctor who conducted a physical exam, as well as blood and urine tests. At home, I researched my symptoms and a cancer called multiple myeloma came up in every corner of my search.
I took my findings to my next appointment with my primary care doc and received the official diagnosis, multiple myeloma. I was too uninformed, I think, to be afraid, even after finding out what we were dealing with not only cancer, but a cancer with no cure.
 

+++ 14:42:19 +++ Paulette: That June in the car on the way home from visiting our mom, Gail pulled over to the side of the road and said, "I have cancer." My first reaction was disbelief. The thought of cancer concerned me and was not something I wanted to see her or us go through. But Gail has always been a self-advocate, very strong-willed and independent.
 

+++ 15:37:22 +++ Gail: I told Paulette first and she became my caregiver. She was front and center in all discussions with my oncologist, asking questions I did not think of and getting clarity where needed. And God bless my doctor. He was wonderful at addressing my concerns and giving us an accurate snapshot of what we were up against. With my doctor's guidance, we decided on an initial treatment.
 

+++ 15:39:48 +++ Paulette: So, led by Miss Fearless, we went through four cycles of a combination chemotherapy regimen. My role was to go with her to her appointments, take notes, share her progress with family, and provide assistance and support in any way that I could.
 

+++ 15:34:40 +++ In December, Gail had a stem cell transplant and by April, she was in near complete remission. She stayed in remission for quite a few years and we became very active in our multiple myeloma support group.
 

+++ 14:34:52 +++ As a co-leader, I began working to develop ways to share information about multiple myeloma in our community.
 

+++ 15:40:53 +++ Several years later, Gail's numbers began to slowly rise, and she in consultation with her oncologist started looking at possible treatment regimens.
 

+++ 14:45:32 +++ Gail: After analyzing all the information available, Paulette, my doctor and I decided that an all oral treatment regimen which included NINLARO would be a good option for me because I had received at least one prior therapy. I felt comfortable with the treatment schedule and the idea of taking my medication at home.
 

+++ 15:42:25 +++ I began my treatment routine with NINLARO and after my first round, my doctor and I noticed I was responding to the therapy. The side effects I experienced, like edema, GI issues and neuropathy, were all detailed in my journal and reported to my doctor. He has since adjusted my dosage to help me manage these side effects.
 

+++ 15:42:51 +++ Keep in mind, these are my experiences and yours could be different.
 

+++ 15:50:56 +++ Paulette: Her doctor noticed that she was responding to the NINLARO regimen. I always encourage her to continue to share her experiences with side effects with her doctor as they happen and not wait until her next appointment. It's important for Gail to keep her doctor informed of how she's feeling so that she can continue to adjust the dose if needed. I've learned so much as I've been on this journey with my sister.
 

+++ 15:51:27 +++ As we continue on this journey, I want to be able to help others. My mission is to encourage multiple myeloma patients and their caregivers to connect with a support group through which they can share their experiences with others, learn as much as they can about the disease and treatment regimens and get emotional support.
 

+++ 14:37:23 +++ Gail: I feel it is my responsibility to share what I learn when and where possible and advocate for people living with myeloma. Yes, multiple myeloma creates life interrupted, but as we look ahead, try to stay positive and explore all the ways in which you can be the best patient and advocate possible.
 

VO: Talk with your doctor to find out if NINLARO is a treatment option for you. Please stay tuned for the Important Safety Information for NINLARO.
 

VO: Important Safety Information for NINLARO
 

NINLARO may cause serious side effects, including:
 

Low platelet counts (thrombocytopenia) are common with NINLARO and can sometimes be serious. You may need platelet transfusions if your counts are too low. Tell your healthcare provider if you have any signs of low platelet counts, including bleeding and easy bruising.
 

Stomach and intestinal (gastrointestinal) problems. Diarrhea, constipation, nausea, and vomiting are common with NINLARO and can sometimes be severe. Call your healthcare provider if you get any of these symptoms and they do not go away during treatment with NINLARO. Your healthcare provider may prescribe medicine to help treat your symptoms.
 

Nerve problems are common with NINLARO and may also be severe. Tell your healthcare provider if you get any new or worsening symptoms including: tingling, numbness, pain, a burning feeling in your feet or hands, or weakness in your arms or legs.
 

Swelling is common with NINLARO and can sometimes be severe. Tell your healthcare provider if you develop swelling in your face, arms, hands, legs, ankles, or feet, or if you gain weight from swelling. Skin reactions. Rashes are common with NINLARO. NINLARO can cause rashes and other skin reactions that can be serious and can lead to death. Tell your healthcare provider right away if you get a new or worsening rash, severe blistering or peeling of the skin, or mouth sores.
 

Thrombotic microangiopathy (TMA). This is a condition involving blood clots and injury to small blood vessels that may cause harm to your kidneys, brain, and other organs, and may lead to death. Get medical help right away if you get any of the following signs or symptoms during treatment with NINLARO: fever, bruising, nose bleeds, tiredness, or decreased urination.
 

Liver problems. Tell your healthcare provider if you get these signs of a liver problem: yellowing of your skin or the whites of your eyes; pain in your right upper stomach-area (abdomen). Other common side effects of NINLARO include low white blood cell counts and bronchitis (neutropenia).
 

Tell your healthcare provider if you get new or worsening signs or symptoms of the following during treatment with NINLARO:

• skin rash and pain (shingles) due to reactivation of the chicken pox virus (herpes zoster)
• blurred vision or other changes in your vision, dry eye, and pink eye (conjunctivitis)

These are not all the possible side effects of NINLARO. Talk to your healthcare provider for medical advice about side effects. You may report side effects to Takeda at 1-844- 217-6468 or FDA at 1-800-FDA-1088. Before taking NINLARO, tell your healthcare provider about all your medical conditions, including if you:

• have liver problems.
• have kidney problems or are on dialysis.
• are pregnant or plan to become pregnant. NINLARO can harm your unborn baby.
   

Females who are able to become pregnant:

• Avoid becoming pregnant during treatment with NINLARO.
• Your healthcare provider will do a pregnancy test before you start treatment with NINLARO.
• You should use effective non-hormonal birth control during treatment and for 90 days after your last dose of NINLARO. If using hormonal contraceptives (for example, birth control pills), you should also use an additional barrier method of contraception (for example, diaphragm or condom). Talk to your healthcare provider about birth control methods that may be right for you during this time.

Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with NINLARO.
Males with female partners who are able to become pregnant:

• You should use effective birth control during treatment and for 90 days after your last dose of NINLARO.
• Tell your healthcare provider right away if your partner becomes pregnant or thinks she may be pregnant while you are being treated with NINLARO.
• are breastfeeding or plan to breastfeed. It is not known if NINLARO passes into breast milk, if it affects an infant who is breastfed, or breast milk production. Do not breastfeed during treatment with NINLARO and for 90 days after your last dose of NINLARO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Talk to your healthcare provider before starting any new medicines during treatment with NINLARO.

Taking too much NINLARO (overdose) can cause serious side effects, including death. If you take more NINLARO than instructed by your healthcare provider, call your healthcare provider right away or go to the nearest hospital emergency room right away. Take your medicine pack with you. 
 

Please see Patient Information in the NINLARO (ixazomib) full Prescribing Information in the prescribing information tab on www.ninlaro.com.

Music Fade Out – No voiceover